All 20 Premier League teams are set to be in action for the first time this season.
Match of the round comes in the form of defending Champions Liverpool vs Transfer Window Champs Chelsea on Monday morning (AEST)
Elsewhere, Manchester United get their campaign underway against Crystal Palace, Wolverhampton look go three straight against City and the Gunners take on the Hammers in a London Derby.
As always our in-house Premier League Prophet has analysed every GW2 fixture and provided his best betting plays along the way.
The Toffees look to secure back-to-back victories to open their season for the first time since 2012.
Carlo’s side looked elite against the Spurs last weekend and should’ve finished the contest further ahead if not for some wayward finishing by Richarlison.
West Brom on the other hand were convincingly dispatched by an understrength Leicester outfit, the newly promoted side struggled generating any real attacking opportunities.
Interestingly Carlo Ancelotti is yet to taste defeat against a newly promoted side in the PL, claiming 11 wins and 4 draws across said fixtures!
Two newly promoted sides go head-to-head in a bid to pick up their first points of the season.
Despite losing, Leeds put together one of the best performances of GW1, pushing the current champs all the way to the brink in a thrilling 4-3 contest.
Marcel Bielsa side finished the Championship on a eight game unbeaten run at home, keeping seven clean sheets across that trip!
Alternatively, the Cottagers trudge into this match-up following a 3-0 humbling against the Gunners.
Fulham will be looking to exercise their demons from their last PL campaign, were they smashed all the wrong record.
Although, Leeds accounted for their Championship rivals 3-0 back in June and have only improved since.
United kick their 2020/21 campaign off this weekend at home against Crystal Palace.
Ole will be hoping to carry on the momentum his side built at the tail end of last season, which saw them finish on a run 14 games without defeat.
Bruno Fernandes was the catalyst for Man U’s success, the Portuguese CAM contributed 12 goals and 8 assists since singing in January, more than any other player in the league.
Crystal Palace managed to grind out a 1-0 victory over Southampton in GW1 with Zaha getting his name on the scoresheet, though tellingly it was their keeper Vicent Guaita who claimed man of the match honours.
The Eagles won their last appearance at Old Trafford, but that fixture was an extreme outlier with the Londoners failing to win the 21 fixtures prior to that result.
Call the season off! The Gunners are on top of the table.
Arsenal saw off Fulham 3-0 in the opening match of the season, with new signing Willian pulling the strings, assisting all three Gunners goals.
Talisman Aubameyang re-signed with the club for another three years, with his new contract seeing him become the highest paid player in the PL, money well spent considering his ridiculous scoring record.
West Ham were largely disappointing in their season opener, going down 2-0 to the Toons at home.
David Moyse has failed to win away to the Gunners across his last 19 attempts, a record which will likely extend to 20 on the weekend.
The Saints and the Spurs will be hoping to get off the mark this weekend, after both sides succumb to 1-0 defeats in their opening fixtures.
Tottenham will be buoyed by the imminent return of their prodigal son Gareth Bale, although the Welshman will more than likely be a ‘fairway’ away from the football pitch this weekend.
The Spurs have failed to keep a clean sheet against Southampton across their last nine meetings, with Danny Ings scoring three times against the North Londoners last season.
Alternatively, Heung-min Son has enjoyed this fixture in the past, scoring seven from his last eleven matches against the Saints.
Despite a poor showing last week, there is plenty of positive energy surrounding the Spurs this campaign and I believe they’ll bet the job done here in a high scoring affair.
This fixture is looming to be an absolute snooze-fest.
These sides have meet in the Premier League on six previous occasions, Brighton have claimed two victories, while the other four fixtures resulted in a draw.
More disgustingly, this fixture has only finished with more than a single goal on just one occasion, with a 0-0 draw occurring three times!
Best bet is to turn your TV off and get some sleep here, but if you really want to back something, the Unders looks like the smart play.
We’re force to wait until early Monday morning (AEST) for the match of the round, when the current champs head to the Bridge to take on this season’s big spenders.
Both the Reds and the Blues escaped GW1 with all three points, despite dishing up less than impressive performances.
Mo Salah was the hero for Liverpool, the crafty Egyptian notched up the first hat-trick of the season, helping his side avoid an embarrassing loss to the newly promoted Leeds.
Meanwhile, Chelsea put on a mediocre display against Brighton, the final score of 3-1 flattered the Blues who were bossed around the ground for the majority of the contest.
Liverpool have the advantage of a healthy squad here and I can easily see the Reds top three having their way with the Blues unsettle backline.
Burnley kick their season off at King Power Stadium as they prepare to take on the Foxes.
Leicester got their season off to a flyer with a 3-0 victory over a flat West Brom outfit.
Jamie Vardy doesn’t look like slowing down with age, the defending golden boot winner opened his account with a double in GW1.
The three last meetings between these sides has resulted with a scoreline of 2-1, two of which Leicester claimed the W.
The Clarets have never won at King Power and with the Foxes finding their grove in GW1 I can’t see them claiming their maiden victory this weekend.
Don’t worry about setting your alarm at 3am Tuesday morning, it’s just Villa v Sheffield United.
The Villans will be looking to build on their 2019/20 end of season run of four games unbeaten, while the Blades will be hoping to bounce back from a 2-0 defeat against the Wolves in GW1.
The Blades are unbeaten against Villa in their last four meetings, with Chris Wilder is yet to taste defeat against a side managed by Dean Smith.
Villa are lucky to be in the PL this season, if not for a VAR howler, they would be plying their trade back in the Championship.
The Blades should dominate across the ground here and I’m more than happy to take them at the current H2H price.
Game Week Two comes to a close on Tuesday morning when Manchester City take the field against Wolverhampton.
A result either way would create history for either side.
The Wolves have an opportunity to record their 2,000th league win and in doing so become the only side to claim three wins on the trot against a Pep Guardiola managed side!
Meanwhile, the Citizen can become the first Premier League side to win their opening fixture 10 seasons straight.
The Wolves are Pep’s boogie side, Nuno’s boys claimed two upsets against the Sky Blues last season, largely off the back of Adama Traore, who netted three times across the trip.
The Citizens have endured and interrupted preseason, with several key players only just retuning to the training pitch following positive Covid tests.
With City in a shambles and Nuno possessing the key to unlock Pep’s free flowing game plan, It’s well worth taking a punt at the Wolves at their current price!